Animal Models for Microbiome Research: Advancing Basic and Translational ScienceInstitute for Laboratory Animal Research
Keck Center of the National Academies
500 Fifth St. NW Washington DC 20001
"foster the integrated study of microbiomes across different ecosystems" pulling together federal agencies, academic institutions and private entities.
Most preclinical research has focused on the mouse as a model organism for delineating the mechanisms that shape the assembly and dynamic operations of microbial communities, for performing preclinical proof-of-concept tests of causal relationships between given community configurations/ memberships and host physiologic, metabolic, immune and neurologic phenotypes; and for developing methods to repair or prevent functional abnormalities in these communities that contribute to disease pathogenesis. This public workshop is designed to examine animal models of microbiome research. Invited speakers will (i) explore how to improve the depth and breadth of analysis of microbial communities using various model organisms; (ii) address the challenges of standardization and biological variability that are inherent in gnotobiotic animal-based research; (iii) examine the predictability and translatability of preclinical studies to humans; and (iv) discuss strategies for expanding the infrastructure and tools for conducting studies in these types of models. They will address gaps, challenges and opportunities in this rapidly expanding field with particular attention to the care, use, and welfare of the gnotobiotic animals.
An individually authored summary of the presentations and discussions at the workshop will be prepared by a designated rapporteur in accordance with institutional guidelines.
This workshop is made possible by generous donations from: The Bill and Melinda Gates Foundation; the American Veterinary Medical Association; Covance Laboratories; Genentech; GlaxoSmithKline; Massachusetts General Hospital; Merck; National Primate Research Centers; National Science Foundation; Novartis; University of California, Davis; University of Michigan; University of Pittsburgh; University of Washington; U.S. Food and Drug Administration; and Yale University.
Workshop Summaries Resulting from this Event
The surface of the human body and its mucous membranes are heavily colonized by microorganisms. Our understanding of the contributions that complex microbial communities make to health and disease is advancing rapidly. Most microbiome research to date has focused on the mouse as a model organism for delineating the mechanisms that shape the assembly and dynamic operations of microbial communities. However, the mouse is not a perfect surrogate fo... More >>