Toxicity Pathway-Based Risk Assessment: Preparing for Paradigm Change: A Symposium Summary (2010)Board on Environmental Science and Toxicology
New tools and technologies are bringing about a revolution in toxicity testing. In 2007, a committee of the National Research Council proposed a vision that embraced recent scientific advances and set a new course for toxicity testing. In this new paradigm, biologically important perturbations in key toxicity pathways are evaluated with new methods in molecular biology, bioinformatics, computational toxicology, and a comprehensive array of in vitro tests based primarily on human biology. Today, new approaches are being developed and are generating new data that need to be evaluated. This summary presents highlights from a May 2009 symposium, convened at the request the U.S. Environmental Protection Agency to stimulate discussion on the application of these approaches and data in risk assessment.