Expert Reports

These reports are unique, authoritative expert evaluations. Each report is produced by a committee of experts selected by the Academy to address a particular statement of task and is subject to a rigorous, independent peer review.

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Showing results 1 - 5 of 155

Review of the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens (2014)

In 2011, the National Toxicology Program listed styrene as "reasonably anticipated to be a human carcinogen" in its 12th Report on Carcinogens. Congress directed the Department of Health and Human Services to request the National Academy of Sciences to review independently the substance profile of styrene and its listing in the Report on Carcinogens. This report presents the findings and conclusions of the committee formed in response to th... More >>

Report in Brief

Review of EPA's Integrated Risk Information System (IRIS) Process (2014)

At the request of Congress, this study evaluates EPA's progress in responding to recommendations from the National Research Council for improving the Integrated Risk Information System (IRIS) process, which is the program responsible for developing toxicologic assessments of chemical contaminants in the environment. The study finds that the changes to the IRIS process that EPA has proposed and implemented to various degrees constitute substantia... More >>

Report in Brief

Review of the Environmental Protection Agency's State-of-the-Science Evaluation of Nonmonotonic Dose-Response Relationships as they Apply to Endocrine Disrupters (2014)

Potential health effects of endocrine-disrupting chemicals raise an environmental health concern about the chemicals' ability to interfere with normal hormone function in humans and wildlife. Some research on endocrine disruptors has identified nonmonotonic dose–response relationships; that is, lower doses are not always associated with smaller responses, nor higher doses with larger responses. Nonmonotonic dose–response curves have been ... More >>

Critical Aspects of EPA's IRIS Assessment of Inorganic Arsenic: Interim Report (2013)

This report reviews critical aspects of the scientific literature on inorganic arsenic and a draft plan by the U.S. Environmental Protection Agency (EPA) that describes how the agency will perform its Integrated Risk Information System (IRIS) assessment of the potential health effects of oral exposure to this chemical. The report finds that EPA's draft plan includes improved approaches for evaluating evidence and conducting analyses but shoul... More >>

Report in Brief

Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 15 (2013)

At the request of the Department of Defense and the Environmental Protection Agency, the National Research Council has reviewed the relevant scientific literature compiled by an expert panel and established Acute Exposure Guideline Levels (AEGLs) for several chemicals. AEGLs represent exposure levels below which adverse health effects are not likely to occur and are useful in responding to emergencies, such as accidental or intentional chemica... More >>