Expert Reports

These reports are unique, authoritative expert evaluations. Each report is produced by a committee of experts selected by the Academy to address a particular statement of task and is subject to a rigorous, independent peer review.

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Showing results 1 - 5 of 161

Using 21st Century Science to Improve Risk-Related Evaluations (2017)

The availability of tools to assess human health risks from chemical exposures have increased rapidly in the 21st century. For example, new personal sensors and sampling techniques offer unparalleled opportunities to characterize individual exposures, new in vitro assays can now evaluate a number of cellular processes and responses, and -omics technologies have advanced molecular epidemiology, which focuses on underlying biology rather tha... More >>

Refinements to the Methods for Developing Spacecraft Exposure Guidelines (2016)

Human spaceflight is inherently risky, with numerous potential hazards posed at each phase of a mission. Some of the potential health risks arise from the effects of microgravity on the body and from the environmental conditions associated with living and working in spacecraft. Several hundred chemicals are likely to be found in the closed environment of the spacecraft, and as the frequency, complexity, and duration of human spaceflight... More >>

Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense (2015)

The US Department of Defense (DOD) is faced with an overwhelming task in evaluating chemicals that could potentially pose a threat to its deployed personnel. There are over 84,000 registered chemicals, and testing them with traditional toxicity-testing methods is not feasible in terms of time or money. In recent years, there has been a concerted effort to develop new approaches to toxicity testing that incorporate advances in systems biology... More >>

Review of California's Risk-Assessment Process for Pesticides (2015)

This report reviews the risk-assessment practices used by the California Department of Pesticide Regulation as part of its mission to ensure the protection of workers and public health. Overall, the study finds that the Department of Pesticide Regulation's risk-characterization documents are comprehensive and follow established risk-assessment practices. However, the bulk of the assessments duplicate much of the work of the US Environmenta... More >>

Sustainability Concepts in Decision-Making: Tools and Approaches for the US Environmental Protection Agency (2014)

Population growth, climate change, and greater consumption of natural resources are just a few of the challenges the US Environmental Protection Agency (EPA) faces in pursuing its mission to protect human health and the environment. The agency has increasingly embraced the use of sustainability tools and approaches for considering the potential social, environmental, and economic effects of agency decisions and actions. This report identifie... More >>

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