Symposium on Toxicity Pathway-Based Risk Assessment





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                            SYMPOSIUM ON
  TOXICITY PATHWAY-BASED RISK ASSESSMENT:
             Preparing for Paradigm Change

Monday, May 11, 2009
  A Paradigm Change on the Horizon
  The New Science
  Pathway-Based Approaches for Hazard ID

Tuesday, May 12, 2009
  Application to Mode-of-Action Analysis
  Challenges and Opportunities for Risk Assessment in the
      Changing Paradigm

Wednesday, May 13, 2009
  What the Future Holds





          Monday, May 11, 2009

A PARADIGM CHANGE ON THE HORIZON

8:30     Welcome and Introduction
Warren Muir
National Academies

8:35     Background on Standing Committee on Risk Analysis Issues and Reviews
Bernard Goldstein
University of Pittsburgh

8:40     EPA Expectations on Symposium
Peter Preuss
U.S. Environmental Protection Agency

8:45     Making Risk Assessment More Useful to Public and Private Decision-Makers in an Era of Paradigm Change
Donald Elliott
Member, Board on Environmental Studies and Toxicology,
National Academies;
Former EPA General Counsel

9:15     Emerging Science and Public Health
Lynn Goldman
Member, Symposium Planning Committee
Member, Standing Committee on Risk Analysis Issues and Reviews
Johns Hopkins Bloomberg School of Public Health

9:45     Toxicity Testing in the 21st Century
Kim Boekelheide
Brown University

10:15     Symposium Roadmap
Lorenz Rhomberg
Chair, Symposium Planning Committee
Member, Standing Committee on Risk Analysis Issues and Reviews
Gradient Corporation

10:45     BREAK
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THE NEW SCIENCE

11:00     Overview of New Science
John Groopman
Johns Hopkins Bloomberg School of Public Health

11:30     Gene-Environment Interactions
George Leikauf
Member, Symposium Planning Committee
University of Pittsburgh

12:00     Tools and Technologies for Pathway-Based Research
Ivan Rusyn
University of North Carolina at Chapel Hill

12:30     LUNCH BREAK
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PATHWAY-BASED APPROACHES FOR HAZARD ID

1:30     ToxCast: Redefining Hazard Identification
Robert Kavlock
U.S. Environmental Protection Agency

2:00     Practical Applications: Pharmaceuticals
William Pennie
Pfizer Global Research and Development

2:30     Practical Applications: Consumer Products
George Daston
Procter & Gamble Company

3:00     BREAK

3:15     Practical Applications: Mixtures
John Groten
Schering-Plough

3:45     Pathway-Based Approaches: A European/REACH Perspective
Thomas Hartung
Johns Hopkins University

4:15     Panel Discussion
Panelists: Speakers and invited panelists
(Charles Auer,
U.S. Environmental Protection Agency (retired);
David Jacobson-Kram,
U.S. Food and Drug Administration)

5:00     BREAK

5:30     Poster Session
See the Symposium's Program Book for a listing of abstracts presented during poster session.

7:00     ADJOURN
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          Tuesday, May 12, 2009

APPLICATION TO MODE-OF-ACTION ANALYSIS

8:30     What is Required for Acceptance
John Bucher
National Institute of Environmental Health Sciences

9:00     Environmental Disease:
Evaluation at the Molecular Level
Kenneth Ramos
University of Louisville Health Science Center

9:30     Dioxin: Evaluation of Pathways at the Molecular Level
Alvaro Puga
University of Cincinnati

10:00     Systems Level Approaches for Understanding Principals of Nanomaterial Biocompatibility
Brian Thrall
Pacific Northwest National Laboratory

10:30     BREAK

11:00     Panel Discussion
Panelists: Speakers and invited panelists
(William Kaufmann,
University of North Carolina, Chapel Hill;
Jonathan Wiener,
Duke University; Past President, Society for Risk Analysis)

12:00     LUNCH
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CHALLENGES AND OPPORTUNITIES FOR RISK ASSESSMENT
IN THE CHANGING PARADIGM

1:00     Dose and Temporal Response
Elaine Faustman
Member, Symposium Planning Committee
University of Washington

1:30     Application of Genomic Dose-Response Data to Define Mode-of-Action and Low-Dose Behavior of Chemical Toxicants
Rusty Thomas
The Hamner Institutes for Health Sciences

2:00     Using PBPK Models to Interpret Dose-Response of
-Omics Data
Gregory L. Kedderis
Independent Researcher and Consultant
Chapel Hill, North Carolina

2:30     Modular Network Modeling of Toxicity Pathways for Extrapolation
Katrina Waters
Pacific Northwest National Laboratory

3:00     BREAK

3:15     Integrating Global Gene Expression and Survival Across 60 Cell Lines: Applications for Risk Assessment
Albert J. Fornace, Jr.
Georgetown University

3:45     The FDA Experience in Analyzing Genomic Data
Federico Goodsaid
U.S. Food and Drug Administration

4:15     Panel Discussion
Panelists: Speakers

5:30     ADJOURN
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          Wednesday, May 13, 2009

WHAT THE FUTURE HOLDS
8:30     Are we "there" yet and Where is "there"?
The Path Forward (1, 5, and 10 years in the future)

A Perspective from EPA
Peter Preuss
U.S. Environmental Protection Agency

A Perspective from NIEHS
John Bucher
National Institute of Environmental Health Sciences

A Perspective from the Chemical Industry
Tina Bahadori
American Chemistry Council

A Perspective from the Pharmaceutical Industry
Roger Ulrich
Calistoga Pharmaceuticals, Inc.

A Perspective from Academia
Helmut Zarbl
University of Medicine and Dentistry of New Jersey

A Perspective from an Environmental Advocacy Group
Gina Solomon
Natural Resources Defense Council

10:30     BREAK

10:45     Panel Discussion
Panelists: Speakers

11:45     Symposium Close
Lorenz Rhomberg
Chair, Symposium Planning Committee
Member, Standing Committee on Risk Analysis Issues and Reviews
Gradient Corporation

12:00     ADJOURN
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Board on Environmental Studies and Toxicology