| Twelfth meeting of the Committee on Emerging Issues and Data on Environmental Contaminants |
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Toxicogenomics and Early Life Exposures
February 8, 2006
Keck Center of the National Academies
Washington, DC |
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| --Session I: Toxicogenomics, Developmental Exposures, and Gene-Environment Interactions-- |
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Chairs
Cheryl Walker, University of Texas, MD Anderson Cancer Center
George Orphanides, Syngenta Central Toxicology Laboratory
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| 8:15 |
Workshop Overview |
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Cheryl Walker |
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| 8:35 |
Early life Exposures and Prostate Cancer Risk: Using Toxicogenomics to Interrogate the Epigenome |
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Shuk-mei Ho, Department of Environmental Health Sciences, University of Cincinnati |
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| 9:10 |
Epigenetic Transgenerational Actions for Endocrine Disruptors on Disease Development: New Paradigm for Disease Etiology. |
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Michael Skinner, Center for Reproductive Biology, Washington State University |
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Audio Clip |
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| 9:45 |
Imprinted Genes and Transposons: Epigenomic Targets Linking Prenatal Nutrition to Adult Disease Susceptibility |
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Randy Jirtle, Department of Radiation Oncology, Duke University Medical Center |
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| 10:20 |
Break |
| 10:35 |
Testing for Developmental Neurotoxicity: Can High-Throughput Systems Help? |
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Theodore A. Slotkin, Dept. of Pharmacology & Cancer Biology, Superfund Basic Research Program, Duke University Medical Center |
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11:10
| Extrapolating Data on Early Life Exposures from Animals to Humans
Robert Brent, Jefferson Medical College, Thomas Jefferson University and Laboratory of Clinical and Environmental Teratology, Alfred I. duPont Hospital for Children. |
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| --Session II: Early Life Exposures, Epidemiology, And Risk Assessment-- |
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Chairs
Frederica Perera, Columbia University 's Mailman School of Public Health and Columbia Center for Children's Environmental Health
Robert Griffin, Center for Mass Media Research College of Communication, Marquette University
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| 12:45 |
Introduction to Molecular Epidemiology of Children's Environmental Health |
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Frederica Perera, Columbia Center for Children's Environmental Health, Columbia University |
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| 1:05 |
Prenatal and Early Postnatal Environmental Exposures and Childhood Asthma Risk |
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Rachel Miller, College of Physicians and Surgeons, Columbia University |
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| 1:35 |
The National Children's Study: Designed to Assess Gene-environment Interactions |
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Peter Scheidt, National Institutes of Health |
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| 2:10-2:25 |
Break |
| 2:25 |
Neurotoxic Effects of Developmental Exposure to Environmental Chemicals |
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Deborah Rice, Environmental and Occupational Health Program, Maine Center for Disease Control and Prevention |
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| 3:00 |
Incorporating Early-Life Susceptility into Risk Assessment: the Example of EPA's Guidance on Early-life Exposure to Carcinogens |
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Tracey J. Woodruff, U.S. Environmental Protection Agency |
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| -Session III: Roundtable Discussion-
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| 3:35 |
Panel Discussion: Applying Advances in Toxicogenomic Research on Early-life Exposures to Children's Environmental Health |
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Moderator: Amy Kyle, School of Public Health, University of California - Berkeley |
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Participants: Jerry Heindel, National Institute of Environmental Health Sciences
Gail McCarver, Birth Defects Research Center, Medical College of Wisconsin
John Quackenbush, Dana Farber Cancer Institute; Harvard University
Anthony Scialli, Sciences International Inc |
| 4:20-4:35 |
Audience discussion with roundtable participants |
| 4:35 |
Concluding Remarks |
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Linda Greer, Natural Resources Defense Council |
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Audio Clip |
| 5:00 |
Adjourn |
