| Fifteenth meeting of the Committee on Emerging Issues and Data on Environmental Contaminants |
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Using Toxicogenomic Research to Understand Disease Mechanisms: An Asthma Case Study
February 8, 2007
Keck Center of the National Academies
Washington, DC
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| Download Suggested Reading List |
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| 9:00 |
Introduction of the Standing Committee |
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Kenneth S. Ramos, Health Sciences Center, University of Louisville |
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Audio Clip |
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| 9:05 |
Introduction to the Workshop |
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Patricia A. Buffler, University of California, Berkeley |
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Audio Clip |
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| 9:20 |
Toxicogenomics: Understanding Lung Disease Susceptibility and Pathogenesis. Overview Comments from the NIEHS Perspective |
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David Schwartz, National Institute of Environmental Health Sciences (NIEHS) |
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Download Presentation Slides | Audio Clip |
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| 10:15 |
The Biology of Asthma: Using Animal Models to Investigate Lung Development and the Impact of Environmental Factors |
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Kent Pinkerton, University of California, Davis |
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Download Presentation Slides | Audio Clip |
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| 10:45 |
Break |
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| 11:00 |
Systems Biology of Complex Lung Disease |
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Naftali Kaminski, University of Pittsburgh Medical Center |
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Download Presentation Slides | Audio Clip |
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| 11:30 |
Airway Gene Expression as a Biomarker for Smoking-related Lung Disease |
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Avrum Spira, Boston University School of Medicine |
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Download Presentation Slides | Audio Clip |
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*please note that a fire alarm occurred halfway through this presentation |
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| 1:00 |
Molecular epidemiology of childhood asthma: Environmental Epigenomic Research in an Urban Cohort |
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Rachel L. Miller, Columbia University College of Physicians and Surgeons |
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Download Presentation Slides | Audio Clip |
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| 1:30 |
Ethical, Legal and Social Implications |
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Gary E. Marchant, Arizona State University |
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Download Presentation Slides | Audio Clip |
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| 2:05 |
Discussion of Ethical, Legal and Social Implications |
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Mark Rothstein, University of Louisville School of Medicine
Discussant : Key ethical and legal aspects |
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Audio Clip |
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Paul Stern, National Research Council
Discussant : Key social issues |
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Download Presentation Notes | Audio Clip |
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| 2:45 |
Break |
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| 3:00 |
Plenary Discussion: Translating Research for Public Health Practice and Policy |
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Panel members will identify opportunities to apply research using toxicogenomic methods to improve public health practice and policy and discuss potential obstacles. |
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Amy D. Kyle, University of California, Berkeley |
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Audio Clip (Introduction to session) |
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Lessons from research on pathogenesis of pulmonary disease:
What are promising ways to use improved understanding of pathogenesis of disease to improve public health practice and policy? Are there additional research needs? What are key communication or policy needs? |
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Joe G. N. Garcia, University of Chicago |
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Variations in susceptibility to environmental agents:
Can findings on individual and population variability in susceptibility to environmental stressors help to target prevention and intervention strategies? What the implications of understanding differences in susceptibility for individuals and populations? Are there pitfalls in obtaining and using this information, and can they be avoided or minimized?
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Gilbert Omenn, University of Michigan |
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Regulatory perspectives:
What are the perspectives of regulatory agencies on actions needed to make it possible to apply research results for studies using toxicogenomic methods?
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Robert Meyer, Food and Drug Administration (FDA) |
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| 4:00 |
Wrap up of Plenary Discussion |
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Audio Clip |
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| 4:15 |
Closing Comments from Committee |
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Audio Clip |
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| 4:30 |
Summary of Workshop |
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Patricia A. Buffler, University of California, Berkeley |
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Audio Clip |
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