Identifying Experts in Support of EPA's IRIS Public Science Meetings
The Integrated Risk Information System (IRIS) program is used by the US Environmental Protection Agency (EPA) to evaluate scientific information on toxicologic effects that may result from exposure to chemical substances in the environment. The IRIS database contains toxicologic information on chemical substances that can be combined with other considerations to make risk management decisions, including regulations. Additional information on the IRIS program is available here.
A 2014 National Research Council (NRC) report, Review of EPA’s Integrated Risk Information System (IRIS) Process, applauded EPA initiatives to involve stakeholders to a greater extent in the IRIS process. The report indicated that early and continuing stakeholder involvement will help EPA address the concerns of diverse stakeholders and should strengthen the quality of IRIS assessments.
Supplementing the IRIS Process for Obtaining Public Input
One of the ways that EPA’s IRIS program seeks public input is by holding public meetings to discuss IRIS assessments under development. As indicated by EPA, members of the public are able to discuss key science topics at IRIS public science meetings at their own initiative by indicating their intent to do so during registration for an upcoming meeting here. To supplement the input provided by those individuals, EPA asked the National Academies of Sciences, Engineering, and Medicine to identify subject-matter experts to contribute to the discussions at IRIS public science meetings. The input provided by experts identified by the Academies is intended to ensure that a range of scientific perspectives on key science topics is represented at the meetings. A few weeks prior to an upcoming meeting, EPA will post an agenda on its website, which includes Academies-identified discussants and any other members of the public who registered at their own initiative.
The Academies' Process for Identifying Expert Participants
After EPA announces the chemicals and key science questions or topics to be discussed at an upcoming public science meeting, Academies staff will solicit suggestions from groups that have an interest in the underlying subject matter, professionals with knowledge and expertise in relevant disciplines, and the general public.
The Academies will select a limited number of individuals after considering each candidate’s availability for participation in the public science meeting, relevant expertise and scientific points of view (or bias) concerning the key science questions provided by EPA, and potential conflicts of interest (such as financial interests).
The names of the experts who have been selected by the Academies to participate in the IRIS public science meeting and their biosketches will be made available on this website in advance of the meeting.
The Academies will reimburse the experts for their travel-related expenses as needed.
On October 26, 2016, EPA will hold an IRIS Bimonthly Public Science Meeting on Ethyl tert-butyl ether (ETBE).
Biosketches of Academies-identified discussants are provided here.
Kathryn Z. Guyton is a Senior Toxicologist at the International Agency for Research on Cancer (IARC), World Health Organization in Lyon, France. She contributes expertise in cancer mechanisms to the IARC Monographs Programme. Before joining IARC, she was a toxicologist at the National Center for Environmental Assessment at the US Environmental Protection Agency. She received her PhD in toxicological sciences from the Johns Hopkins Bloomberg School of Public Health. Dr. Guyton has been certified as a Diplomate of the American Board of Toxicology since 1998.
James Klaunig is a Professor and Director of Toxicology in the Department of Pharmacology and Toxicology at Indiana University School of Medicine. His research has focused on the mechanisms of chemically-induced carcinogenesis with emphasis on epigenetic modes of action. His work has concentrated on studies involving multistage liver carcinogenesis with emphasis on the role of oxidative stress/oxidative damage, Kupffer cell activation, modulation of gap junctions, and cell growth/apoptosis in this process. Dr. Klaunig received his MA in biology from Montclair State University and his PhD in pathology and toxicology from the University of Maryland School of Medicine.
David E. Malarkey is a Veterinary Pathologist and Head of the National Toxicology Program’s Pathology Group, which oversees pathology-related issues at all stages of the program’s two-year rodent toxicology/carcinogenesis studies, including study design and management, analysis, peer review, and reporting of all pathology-related data generated during the conduct of studies. He has over 25 years of experience as a pathologist, 23 in the area of toxicological pathology. His group collaborates with other NIEHS as well as extramural investigators in evaluating, interpreting, and reporting on the mechanisms of disease. Dr. Malarkey’s research interests are in the molecular basis of murine hepatocarcinogenesis and hepatotoxicity, toxicological pathology and chemical carcinogenesis, and animal models of carcinogenesis and pathology of genetically altered mice. He received his DVM from Tufts University, and his PhD in pathology and biotechnology from North Carolina State University. He is a Diplomate and current President of the American College of Veterinary Pathologists.
Ivan Rusyn is a Professor in the College of Veterinary Medicine and Biomedical Sciences at Texas A&M University. His research involves applying molecular, biochemical, genetic, genomic, and computational approaches to the understanding of the mechanisms of environmental-agent-related organ injury and carcinogenesis. Recent work has focused on the molecular mechanisms of phthalate-induced carcinogenesis, mechanisms of ethanol-induced hepatic toxicity based on the latest knowledge of the genetic diversity of the mouse as a model organism, and genomic and genetic analysis of hepatic and renal toxicity of trichloroethylene to determine what genetic variants correlate with susceptibility or resistance to hepatic disease. Dr. Rusyn received his MD from the Ukrainian State Medical University in Kiev and his PhD in toxicology from the University of North Carolina, Chapel Hill.
Vasilis Vasiliou is a Professor in the Department of Environmental Health at the Yale School of Public Health. His research interests include mechanisms of cellular responses to environmental stress, gene-environment interactions, alcohol toxicity, pharmacogenetics, and the evolution of gene families. His research focuses on the role of aldehyde dehydrogenases (ALDHs), cytochrome P-450s, and glutathione (GSH) in metabolism and disease (specifically alcohol-induced tissue injury, diabetes, gout, and cancer). Currently, his laboratory studies the roles of corneal crystallins (ALDH3A1 and ALDH1A1) in cellular defense mechanisms against UV-radiation, ALDH1B1 and other alcohol metabolizing enzymes in human colon cancer, ALDH16A1 in gout, and ALDH7A1 in pyridoxine-dependent adolescent epilepsy. Dr. Vailiou’s laboratory also studies the role of many ALDHs in cancer stem cells. Other areas of active research include delineation of the involvement of brain ethanol metabolism in alcohol drinking preference and examination of GSH as a signaling molecule in anterior eye development and in diabetes. Dr. Vasiliou received his PhD in biochemistry from the Medical School of the University of Ioannina, Greece, and he was trained in Molecular and Environmental Toxicology at the University of Cincinnati Medical College.
Academies-Identified Discussants for Previous Meetings
Biosketches of Academies-Identified Discussants for Participation in the June 2016 EPA IRIS Public Science Meeting on tert-Butyl Alcohol (TBA) and Benzo[a]pyrene (BaP).
Sheue-yann Cheng is a senior investigator in the Laboratory of Molecular Biology in the Center for Cancer Research at the National Cancer Institute (NCI). Her research focuses on understanding the biology and molecular actions of thyroid hormone receptors in health and disease. Dr. Cheng’s work has involved creating mouse models for studying the molecular genetic events underlying thyroid carcinogenesis. She is a recipient of the National Institutes of Health (NIH) Merit Award for outstanding achievements, the Scientific Achievement Award from the Chinese Medical and Health Association, the Charles Harkin Award of the NCI, the Sidney H. Ingbar Distinguished Lectureship Award of the American Thyroid Association, and the Abbott Thyroid Research Clinical Fellowship Mentor Award of The Endocrine Society. She served as a regular member of the NIH Molecular and Cellular Endocrinology Study Session and as an advisor for Howard Hughes Medical Institute-NIH Research Scholars. Currently she is a Women Scientist Advisor of the Center of Cancer Research, NCI and is on the Editorial Boards of several prominent journals. Dr. Cheng obtained her Ph.D. from the University of California, San Francisco Medical Center. She received her postdoctoral training at the University of Chicago and the National Institute of Diabetes and Digestive and Kidney Diseases.
Samuel Cohen is the Havlik-Wall Professor of Oncology at the University of Nebraska Medical Center. His research is on mechanisms of carcinogenesis, with a focus on the role of cell proliferation in the carcinogenic process. Most recently this has involved investigations into the mechanisms of bladder carcinogenesis produced by arsenicals and PPAR agonists. In addition, his research has involved clinical investigations of various aspects of urologic pathology and extrapolation between animals and humans. Dr. Cohen has at times acted as an independent consultant to industrial organizations, including LyondellBasell Industries. He was president of the Carcinogenesis Specialty Section of the Society for Toxicology, and was the recipient of the society’s Arnold J. Lehman Award in 2001. He received his MD and PhD in experimental oncology from the University of Wisconsin.
Lawrence Lash is professor of pharmacology at Wayne State University. His research interests are in the development of in vitro models to study the biochemical and molecular mechanisms that underlie renal toxicity, trichloroethylene metabolism and mechanisms of renal cell injury, and glutathione metabolism and transport. Other interests include studying diabetic neuropathy and mitochondrial function in rats and the molecular toxicology of solvents in human kidney cells. Dr. Lash is the editor of the third edition of Toxicology of the Kidney. He received his PhD in biochemistry from Emory University.
Thomas Rosol is professor of veterinary pathology at Ohio State University. He has served as dean of the College of Veterinary Medicine and senior associate and interim vice president for research at the university. His laboratory investigates the pathogenesis of cancer-associated hypercalcemia, animal models of human cancer, and endocrine-responsive cancers. Dr. Rosol has served on numerous scientific advisory panels, including those of the National Institutes of Health, the US Department of Agriculture, the American Veterinary Medical Association, and the Morris Animal Foundation. He serves as a consultant for industry in preclinical safety in the areas of endocrine, bone, and reproductive pathology and animal models of cancer. He received his DVM from the University of Illinois and his PhD in pathobiology from Ohio State University. He is a diplomate of the American College of Veterinary Pathologists.
Jerrold Ward is a consultant in veterinary pathology, providing pathology services in toxicologic pathology, rodent pathology, tumor pathology, carcinogenesis, immune system pathology, and genetically-engineered mice. He was formerly chief of the Veterinary and Tumor Pathology Section in Center for Cancer Research at the National Cancer Institute (NCI), and head of Tumor Pathology at the National Toxicology Program (NTP). Dr. Ward was involved in the early development of the NCI bioassay program, publication of the first 200 NCI and NTP carcinogenesis bioassay reports, and was a member of the NTP Technical Reports Subcommittee of the NTP Board of Scientific Councilors. Dr. Ward received his DVM from Cornell University and his PhD in comparative pathology from the University of California, Davis. He is board-certified as a diplomate of the American College of Veterinary Pathologists.
Michèle Bouchard is professor in the Department of Environmental and Occupational Health at the University of Montreal. Her research interests are in assessing toxicological health risks in humans associated with environmental and occupational exposures to chemical compounds through the use of biomonitoring and toxicokinetic modeling. Contaminants of interest include natural pyrethrins, organophosphorus insecticides, carbamates, polychlorinated biphenyls, and polycyclic aromatic hydrocarbons. She received her Ph.D. in public health from the University of Montreal.
Annette Bunge is professor emeritus in the Department of Chemical and Biological Engineering at the Colorado School of Mines. Much of her early research was on remediating chemically contaminated soils and developing membrane separation methods for wastewater cleanup. These research areas led to her focus of the past 20 years: absorption of chemicals into and through human skin. Her goal is to understand the mechanisms of skin barrier function, with the objective of predicting dermal absorption of chemicals from a variety of media (e.g., liquids, particulate materials, and solid residues) under diverse circumstances (e.g., medical, environmental and occupational). Dr. Bunge received her PhD in chemical engineering from the University of California, Berkeley.
Richard Corley is laboratory fellow in the systems toxicology group at the Pacific Northwest National Laboratory operated by Battelle for the US Department of Energy. He specializes in the development of physiologically based pharmacokinetic models and multiscale computational fluid-dynamics–based models. He has published numerous peer-reviewed papers in toxicology, pharmacokinetic modeling, and cross-species dosimetry applications in human health risk assessments. Dr. Corley was member of the National Research Council Committee to Review EPA’s Draft IRIS Assessment of Formaldehyde, Committee on Risk Analysis Issues and Reviews, and Committee to Assess the Health Implications of Perchlorate Ingestion. He received his PhD in environmental toxicology and veterinary biosciences from the University of Illinois at Urbana-Champaign.
Joanna Jaworska is a principal scientist with Procter and Gamble in Brussels, Belgium. She has expertise in computational modeling and simulation and has been working on dermal penetration models for several years. She helped develop a framework that incorporated the impact of exposure scenarios and application conditions on risk of chemicals applied to the skin. She obtained her PhD in computational toxicology from the University of Tennessee, Knoxville.
John Kissel is professor in the Department of Environmental and Occupational Health Sciences at the University of Washington School of Public Health. He is an environmental engineer whose research focuses on human exposure to environmental contaminants. His is a former president and councilor of the International Society of Exposure Science and former chair of the Exposure Assessment Specialty Group of the Society of Risk Analysis. His research interests are in dermal exposure and absorption, risk assessment, hazardous waste management, soil cleanup, and water quality. Dr. Kissel received his MS in environmental engineering from Harvard University and his PhD in civil engineering from Stanford University.
Anthony Knafla is president of Equilibrium Environmental Inc., in Calgary, Alberta. He has worked as a toxicologist and risk assessor in Canada for over 20 years. Mr. Knafla has developed toxicological profiles and methods for deriving soil quality guidelines that have been applied at provincial and federal levels for chemicals, such as lead, arsenic, perfluorooctanoic acid, polycyclic aromatic hydrocarbons, and mercury. He was involved in deriving a dermal slope factor for benzo[a]pyrene in soil that was published in 2011. Mr. Knafla has also been involved in scientific advisory roles in public hearings and consultation to the Alberta Energy and Utilities Board, Alberta Environment, the Canadian Council for Ministers of the Environment, Environment Canada, and Health Canada. He received his MSc in medical sciences (toxicology) from the University of Calgary, and is a diplomate of the American Board of Toxicology.
Biosketches of Academies-Identified Discussants for Participation in the May 2016 EPA IRIS Public Science Meeting on RDX
Maria Braga is a Professor of Anatomy, Physiology and Genetics in the F. Edward Hebert School of Medicine at Uniformed Services University of the Health Sciences (USUHS). She has more than 25 years' experience working in the field of cellular neurophysiology, neuropharmacology and neurotoxicology. Her research interests in the toxicology field focus on characterizing the underlying mechanisms involved in the neurotoxic effects of environmental pollutants, such as heavy metals, pesticides, and military explosives, at peripheral and central nervous system (CNS) synapses. She began this research during her graduate studies at the University of Strathclyde in the UK, continued during her post-doctoral fellowship at the University of Maryland, and it is a part of her investigations carried out at USUHS. By utilizing a multi-disciplinary approach, she identified several important mechanisms underlying the neurotoxic effects of heavy metals (such as cadmium and lead), pesticides (such as methamidophos and paraoxon), and military explosives (such as RDX) at the neuromuscular transmission, in the hippocampus, and the amygdala. The results of her investigations are described in more than 100 scientific journal manuscripts, technical reports and scientific meeting abstracts published in internationally recognized journals and conference proceedings. She has served on numerous review committees for the National Institutes of Health, congressionally directed Medical Research Programs, Department of Veterans Affairs, Veterans Health Administration, Defense Treat Reduction Agency, and Medical Research Council (UK). Dr. Braga received a Ph.D. in physiology and pharmacology from the University of Strathclyde, Scotland.
Marion Ehrich is a professor at the Virginia-Maryland Regional College of Veterinary Medicine in Blacksburg, VA, and at the Virginia Tech Carilion School of Medicine in Roanoke. In addition to teaching pharmacology and toxicology to veterinary, medical and graduate students, her professional responsibilities include service in the Veterinary Medical Teaching Hospital Pharmacy and in the Toxicology Diagnostic Laboratory. She has been teaching at VMRCVM since 1980, the year in which she became a member of the Society of Toxicology and a Diplomate of the American Board of Toxicology. Teaching at the new medical school began in 2010. She was elected a fellow of the Academy of Toxicological Sciences in 1999. Dr. Ehrich’s primary research activities are associated with the comparative neurotoxicities of antiesterase pesticides, with both in vivo and in vitro models used for study. Dr. Ehrich was the 2003-2004 President of the Society of Toxicology, and received their Merit Award in 2010. She served as Treasurer for the Board of Directors of the American Board of Toxicology (1985-89) and as Secretary for the Society of Toxicology (1992-94). She has also chaired SOT’s Education Committee (1990-92), SOT’s Regulatory Affairs and Legislative Action Committee (1997-98), and the Toxicology Education Foundation (2000-2001). In addition, she served on the Executive Board of the Council for Scientific Society Presidents and the National Research Council’s Committee on Toxicology, and currently serves on the USP Committee on Toxicology. She is on editorial boards NeuroToxicology, In Vitro Toxicology, and Journal of Applied Toxicology and is an associate editor for the International Journal of Toxicology. Dr. Ehrich received a Ph.D. in pharmacology and toxicology from the University of Connecticut at Storrs.
Kendall Frazier is a director of pathology at GlaxoSmithKline (GSK), where he has been employed for more than 14 years. His primary duties at GSK are both as a senior scientific consultant and toxicologic study pathologist, and he is a member of the Nephrology Safety Panel. His current research interests include mechanisms of drug-induced toxic responses in the urinary system. Dr. Frazier has held staff appointments at the University of Miami School of Medicine and at the University of Georgia School of Veterinary Medicine. His focus while in academia was on the development of rodent models of kidney failure and mechanisms of both toxic and infectious renal disease. He has authored more than 75 scientific journal publications and book chapters. He chaired the Urinary System subcommittee for the Society of Toxicologic Pathology's (STP) INHAND nomenclature initiative, and has chaired many other committees and meetings for the STP, the American College of Veterinary Pathologists (ACVP), and other organizations, such as the World Pharma Congress. Dr. Frazier has served on the editorial boards of multiple scientific journals, and is currently a member of the editorial board of Toxicologic Pathology. He is a fellow of the International Academy of Toxicologic Pathology. He completed a residency in comparative pathology at University of Miami's Jackson Memorial Hospital and is board certified in both Pathology and Toxicology. He holds a D.V.M. from Kansas State College of Veterinary Medicine and a Ph.D. in molecular biology from the University of Miami.
Andy Nong is the lead computational toxicologist of Health Canada and he serves as the principal investigator of the Computational Toxicology Laboratory that is part of the Health Canada Environmental Health Sciences and Research Bureau. His research focuses on computer models of biological systems that can be applied to understand and predict the fate of a chemical dose in the body and its possible health effects. The work explores different types of computing approaches (pharmacokinetic models, benchmark dosing, chemical structure-activity regression, and systems-biology models) that can help to evaluate chemical safety. The models are also used to estimate population exposures and interpret Canadian biomonitoring data. Before coming to Health Canada, Dr. Nong worked as a research investigator and postdoctoral fellow at the Hamner Institutes for Health Sciences. He also served on various committees of a number of organizations, including the World Health Organization International Programme on Chemical Safety, Genome Canada, and the Joint Research Centre European Union Reference Laboratory for Alternatives to Animal Testing (JRC EURL-ECVAM). In addition, he served as a member of the National Academy of Sciences Committee on Predictive-Toxicology Approaches for Military Assessments of Acute Exposures. Dr. Nong received a Ph.D. in public health and toxicology from the University of Montreal.
Karen Regan is a toxicologic pathology consultant engaged in assessing and interpreting morphologic pathology and toxicology data for regulatory submissions. Over the past 25 years, she has served in various pathology and management roles at contract research organizations and at her own independent consultancy. Dr. Regan has served as vice president and president of the Toxicologic and Exploratory Specialty Section and as secretary and treasurer of the Carcinogenicity Specialty Section of the Society of Toxicology. She is currently a counselor for the Society of Toxicologic Pathology, and she has been actively engaged in the standardization of nomenclature for toxicologic pathology. Dr. Regan’s interests are reproductive pathology, neuropathology and ototoxicity. She has served as an expert pathologist on multiple pathology working groups and she currently serves on the FDA Non-Clinical Studies Section reproductive pathology advisory group. Dr. Regan served on the National Toxicology Program Technical Reports Peer-Review Panel. In addition, she has served on the editorial board of Veterinary Pathology, and is a reviewer for the journals Toxicologic Pathology and Veterinary Pathology. She received a DVM from Ohio State University and completed a morphologic pathology residency at the University of Illinois, followed by an NIH postdoc at the University of Notre Dame.
Evelyn Tiffany-Castiglioni is Associate Dean of Undergraduate Education at the Texas A&M University College of Veterinary Medicine & Biomedical Sciences. In addition, she is a professor and Department Head of Veterinary Integrative Biosciences at the college. Dr. Tiffany-Castiglioni also is a member of the faculty of toxicology and the faculty of neuroscience at Texas A&M. Her research areas include cell biology, toxicology, and neuroscience. Her primary research interests are neurotoxicology and in vitro toxicology, particularly the mechanisms by which brain cells called astrocytes handle toxic metals. Astrocytes are the main depot for several metals in the brain and also serve protective roles against oxidative damage. She serves as associate editor of the journal Neurotoxicology and as a member of the editorial board of the International Journal of Developmental Neuroscience. Dr. Tiffany-Castiglioni edited the book In Vitro Neurotoxicology: Principles and Challenges (Humana Press). She received a Ph.D. in human genetics and cell biology from the University of Texas Medical Branch at Galveston.
Biosketches of Academies-Identified Discussants for Participation in the June 2015 EPA IRIS Public Science Meeting on Polychlorinated Biphenyls
David O. Carpenter is a public health physician who serves as director of the Institute for Health and the Environment at the State University of New York at Albany. He is also a professor of environmental health sciences at the university’s School of Public Health and previously served as its dean. In addition, Dr. Carpenter served as director of the Wadsworth Center of the New York State Department of Health. He has more than 370 peer-reviewed publications, 6 books and 50 reviews and book chapters to his credit. His more recent work focuses on the study of human disease resulting from exposure to environmental contaminants. Dr. Carpenter has conducted a number of studies of PCB-exposed human populations in locations such as Alabama, Alaska, Massachusetts, and New York. He served as a member of the International Agency for Research on Cancer (IARC) panel that declared all polychlorinated biphenyls (PCBs) as Group 1, known carcinogens. He also served as a member of the Institute of Medicine’s Committee on Implications of Dioxin in the Food Supply. Dr. Carpenter received an M.D. from Harvard Medical School.
Jeffery M. Gearhart is a senior toxicologist at the Henry M. Jackson Foundation for the Advancement of Military Medicine, a non-profit foundation dedicated to advancing military medical research in support of the Uniformed Services University of the Health Sciences and throughout military medicine. He leads and directs select human health risk and toxicology projects related to occupational exposure standards and the pharmacokinetics and pharmacodynamics of chemicals relevant to the U.S. Department of Defense and Air Force. Dr. Gearhart specializes in the development and application of computational toxicological models to assess human health risk for inhalation exposure standards for pilots of high performance aircraft, human/animal responses to inhalation of chemical warfare agents, infectious biological agent inhalation deposition, occupational exposure standards for metals, and personal care product inhalation safety. He is a diplomat of the American Board of Toxicology, and authored more than 100 scientific journal manuscripts, technical reports and scientific meeting abstracts. Dr. Gearhart received a Ph.D. in environmental health sciences from New York University.
Gary L. Ginsberg is a toxicologist in the Connecticut Department of Public Health Division of Environmental and Occupational Health Assessment. He is involved in the use of toxicology and risk-assessment principles to evaluate human exposure to chemicals in air, water, soil, food, and the workplace. He has published in toxicology, carcinogenesis, physiologically based pharmacokinetic modeling, interindividual variability, and children’s risk assessment. He also holds an adjunct faculty position at the Yale School of Medicine and is an assistant clinical professor at the University of Connecticut School of Medicine. Dr. Ginsberg served on several recent review panels of EPA’s Science Advisory Board. He currently serves on the National Research Council (NRC) Committee on Inorganic Arsenic, and he previously served on the NRC Committee on Improving Risk Analysis Approaches Used by the U.S. EPA and the NRC Committee on Human Biomonitoring for Environmental Toxicants. Dr. Ginsberg received a Ph.D. in toxicology from the University of Connecticut.
Larry G. Hansen is professor emeritus in the Department of Veterinary Biosciences in the College of Veterinary Medicine at the University of Illinois, Urbana-Champaign. His research activities included assessments of PCB-mixture exposure profiles, bioaccumulations, and toxicities in humans and other organisms, the transfer of PCBs through food animals, and the concept of disruption of reproduction through endocrine effects with PCBs as the model agonist. He has produced about 200 publications including a book (“PCBs: Human and Environmental Disposition and Toxicology” in 2008), conference proceedings, reviews and text book chapters as well as original research papers and contributions to ATSDR's Tox Profile for PCBs. Dr. Hansen received a Ph.D. in toxicology from North Carolina State University.
Susan A. Korrick is an assistant professor of medicine at the Channing Laboratory, Harvard Medical School and an assistant professor in the Department of Environmental Health at the Harvard School of Public Health. In addition, she is a physician with specialty training in environmental and occupational medicine and an associate physician in the Department of Medicine at Brigham and Women’s Hospital, Boston, MA. Her research is in the area of environmental epidemiology, with an emphasis on human exposures to environmental chemicals (including polychlorinated biphenyls) and effects on cognitive and behavioral function and reproductive health and development. Dr. Korrick is a member of EPA’s Science Advisory Board’s Drinking Water Committee. In addition, she served as a member of the Institute of Medicine Committee to Review ATSDR's Great Lakes Reports. Dr. Korrick received an M.D. from Yale University, and an M.P.H. from the Harvard University School of Public Health. She is board certified in both internal medicine and occupational medicine.
Pieter J.J. Sauer is a professor and former chair of the Department of Pediatrics, University Hospital at the University of Groningen, the Netherlands. His research interests include nutrition, growth, and development in infants, specifically with respect to the effects of environmental contaminants, such as polychlorinated biphenyls, on health and development in children. Dr. Sauer is a member of the National Health Council (the Netherlands) and the Neonatology Group of the Dutch Society of Pediatrics. He is a former president of the International Pediatric Research Foundation. Dr. Sauer served as a member of the Institute of Medicine’s Committee on Implications of Dioxin in the Food Supply. He has been European chief editor of the journal Pediatric Research. Dr. Sauer received an M.D. from the University Medical Centre Groningen.
Peter S. Thorne is professor and head of the Department of Occupational and Environmental Health at the University of Iowa, College of Public Health. Dr. Thorne is associate director and co-founder of the Interdisciplinary Graduate Program in Human Toxicology. He is the director of the NIH-funded Environmental Health Sciences Research Center at the University of Iowa and principal investigator of the AESOP Project (a community-based research study) and the Inhalation Toxicology Core for the Iowa Superfund Research Program. His research addresses environmental risk factors for asthma, health effects of inhaled air pollutants (including polychlorinated biphenyl congeners), inflammatory lung diseases, endotoxin-induced immunomodulation, nanotoxicology, and novel methodology for exposure assessment to airborne toxicants. He has published over 210 peer-reviewed journal articles. Dr. Thorne has served on a wide variety of editorial and review boards for scientific journals, government agencies, and academia. From 2003 to 2006, he served on the NIH National Advisory Environmental Health Sciences Council. He has served for three years on the U.S. EPA Chartered Science Advisory Board and is now chair of that board. Dr. Thorne is a member of the National Research Council’s Board on Environmental Studies and Toxicology. He received a Ph.D. in toxicology from the University of Wisconsin-Madison, and completed post-doctoral training in immunotoxicology at the University of Pittsburgh.
Marc-André Verner is an assistant professor in the Department of Occupational and Environmental Health in the School of Public Health at the University of Montreal. In addition, he is a research associate at the Harvard School of Public Health, collaborates with the Norwegian Public Health Institute, and consultants for the Hamner Institutes for Health Sciences. His research areas are in toxicology and environmental epidemiology, and he develops mathematical models to estimate children’s exposure to environmental contaminants for assessing the health risks of early exposures. Dr. Verner’s work includes evaluating potential risks to infants from consuming human milk containing polychlorinated biphenyl congeners. He received a Ph.D. in biology from the University of Quebec at Montreal.
Biosketches of Academies-Identified Discussants for Participation in the February 2015 EPA IRIS Public Science Meeting on Specified Phthalate Chemicals
Kim Boekelheide is professor of pathology and laboratory medicine at the Brown University School of Medicine and director of the Brown University Superfund Research Program. His research examines fundamental molecular mechanisms by which environmental and occupational toxicants induce testicular injury. Current projects include the development of novel in vitro approaches to safety assessment, use of xenotransplantation approaches for human-relevant toxicity testing, and the discovery of sperm molecular biomarkers that reflect testicular injury. Among his various advisory activities, he served as a member of the National Research Council Committee on the Use of Emerging Science for Environmental Health Decisions and the Committee on Toxicity Testing and Assessment of Environmental Agents. Dr. Boekelheide received a PhD in pathology and an MD from Duke University.
Pam Factor-Litvak is associate professor of clinical epidemiology and environmental health sciences at the Columbia University Medical Center. Her current research interests concern the biological relationships between environmental exposures and development. Dr. Factor-Litvak is particularly interested in in-utero and early childhood exposures to heavy metals (e.g. lead, mercury), endocrine disrupting compounds (e.g. PCBs, organohalogen pesticides), and developmental and reproductive outcomes in late childhood, adolescence and adulthood. One example of her current work is to ascertain whether prenatal exposure to endocrine disrupting compounds is associated with persistent neurobehavioral problems and reproductive disorders in males. She has served on numerous National Institutes of Health review committees and a World Health Organization expert panel on endocrine disrupting chemicals. Dr. Factor-Litvak received a PhD in epidemiology from Columbia University.
Russ Hauser is the Frederick Lee Hisaw Professor of Reproductive Physiology and Professor of Environmental and Occupational Epidemiology in the Department of Environmental Health at the Harvard School of Public Health. He also has an appointment at Harvard Medical School where he is Professor of Obstetrics, Gynecology and Reproductive Biology. Dr Hauser’s research focuses on the health risks of exposure to environmental chemicals that adversely affect human development and reproductive health. He is the principal investigator of three NIH funded studies on the health effects of environmental chemicals on infertility and pregnancy outcomes. He is also conducting an NIH funded study in Russia on the impact of environmental chemicals on children’s health. He served on two committees of the Institute of Medicine, National Academies of Science, on Gulf War and Health and one committee on Veterans and Agent Orange. Dr. Hauser served on the National Research Council committee that prepared the report entitled: “Phthalates and Cumulative Risk Assessment: The Tasks Ahead.” Dr. Hauser is a member of two US EPA Science Advisory Boards. He served on the US Consumer Product Safety Commission’s Chronic Hazard Advisory Panel examining the effects of phthalates on children’s health. Dr. Hauser is an advisory board member of Environmental Health Perspectives--a journal of the National Institute of Environmental Health Sciences. Dr. Hauser has served as the chair of the Environment and Reproduction Special Interest Group, American Society for Reproductive Medicine. He received an MD from Albert Einstein College of Medicine and an MPH and ScD from the Harvard School of Public Health, where he completed a residency in occupational medicine. He is board certified in occupational medicine.
Richard Ivell is a special joint professor in the School of Biosciences and School of Veterinary Medicine and Science at the University of Nottingham in the United Kingdom. His previous positions include head of reproductive endocrinology at the Leibniz Institute for Farm Animal Biology in Dummerstorf, Germany, and professor of biochemistry and head of the School of Molecular and Biomedical Sciences at the University of Adelaide in Australia. Dr. Ivell is a molecular endocrinologist specializing in the development of reproductive function in mammals and in understanding how environmental endocrine disrupting chemicals (EDCs) affect human and animal health through their influence on early (fetal) development. His current research is focusing on the molecular mechanisms of differentiation which regulate the physiology of reproductive processes, with emphasis on ovarian, endometrial and myometrial function in the female and testicular physiology in the male. This interest has extended to understanding the molecular basis of the aging process within the testis, specifically of the steroidogenic Leydig cells. Dr. Ivell has been invited to chair sessions at International Workshops on Environmental Endocrine Disruption in Copenhagen, Denmark, in 2004 and 2006. He was editor-in-chief of the international journal Molecular Human Reproduction. Dr. Ivell received a PhD from City University, London, United Kingdom and the Ecole Polytechnique, France.
Rita Loch-Caruso is professor of environmental health sciences, and director of the Environmental Toxicology and Epidemiology Program at the University of Michigan School of Public Health. Her research focus is on female reproductive toxicology and, in particular, mechanisms of toxicity related to adverse pregnancy outcomes, such as premature birth. Dr. Loch-Caruso has conducted research on the effects of several environmental toxicants (such as phthalates, lindane, PCBs and DDT) on the functions of the uteroplacental tissues that are critical for parturition. Her research investigations include molecular, biochemical, cellular, tissue, and whole animal approaches, as well as collaborations that interface with human subjects research. Particular emphasis is placed on the development and utilization of cell and tissue culture systems. In addition to university-related activities, she has served on numerous local, state and national committees including the City of Ann Arbor Environmental Commission, National Institutes of Health grant review panels, and the Institute of Medicine Committee on Understanding Premature Birth and Assuring Healthy Outcomes. Dr. Loch-Caruso received a PhD in toxicology from the University of Cincinnati.
Sheela Sathyanarayana is an associate professor of pediatrics and adjunct associate professor within the Department of Environmental and Occupational Health Sciences at the University of Washington. Dr. Sathyanarayana serves as the co-director of the Pediatric Environmental Health Specialty Unit in Region X where she performs environmental health consults for health care professionals, government entities, and individual families related to environmental exposures and children’s health. Her research interests focus on exposures to endocrine disrupting chemicals, including phthalates and bisphenol A, and their impact on hormone-mediated child development. Dr. Sathyanarayana served as the center director and clinical director for The Infant Development and Environment Study which is a multi-center cohort study of phthalate exposures in pregnancy and health outcomes in children. She was named the 2012 Outstanding New Investigator within the University of Washington Center for Ecogenetics and Environmental Health (CEEH). She currently serves as chair for the US Environmental Protection Agency’s Children’s Health Protection Advisory Committee. Dr. Sathyanarayana received an MD from the University of Southern California and an MPH from the University of Washington.