ILAR Journal

Recent Issues of the ILAR Journal


Volume 54, Issue 3

Animal Models of Peripheral Neuropathy

Scientific Editor:Joanna Brell

 

This issue of the ILAR Journal explores research on peripheral neuropathy and how animal models are assisting in investigating this pervasive condition. Peripheral neuropathy manifests in a variety of symptoms and as such, a major challenge in using animal models to study peripheral neuropathy is their inability to communicate exactly what their symptoms feel like. Similarly, due to the varied expression of peripheral neuropathy, animal models may also present the best avenue with which to investigate the condition. This journal's papers depict the best use of a variety of animal models in researching a variety of manifestations of this condition, including PN due to diabetes mellitus, autoimmune disease, HIV, leprosy and external conditions. A paper clarifies the monitoring of laboratory animal welfare, and another brings in NIH standards for the use and care of animal model research. 

 

Contents:

  • Animal Models of Peripheral Neuropathy: Modeling What We Feel, Understanding What They Feel
  • Mouse Models of Diabetic Neuropathy
  • Rodent Models of Chemotherapy-Induced Peripheral Neuropathy
  • Animal Models of Autoimmune Neuropathy
  • Drosophilia Models of Neuronal Injury
  • Unraveling the Pathogensis of HIV Peripheral Neuropathy: Insights from a Simian Immunodeficiency Virus Macaque Model
  • The Armadillo as a Model for Peripheral Neuropathy in Leprosy
  • Animal Models of Peripheral Neuropathy Due to Environmental Toxicants
  • What Investigators Need to Know About the Use of Animals
  • Institutional Animal Care and Use Committee Considerations for Animal Models of Peripheral Neuropathy

Volume 54, Issue 2

Progress in Genetics and Genomics of Nonhuman Primates

Scientific Editor: John D. Harding

 

The papers in this issue of the ILAR Journal discuss the current understanding of the genetics and genomics of apes (particularly the chimpanzee), and old world monkeys, such as macaques, baboons, and vervets. These species provide highly relevant models for many aspects of human physiology, behavior, and disease. They also enhance the understanding of evolutionary biology and have been used widely for many aspects of discovery science. As directly related to translational research, monkeys, in particular, are used extensively to test the efficacy of vaccines, therapies for human disease, and for examining the toxicity of drug candidates. Classic examples of the importance of nonhuman primates (NHPs) used for translational research are the development of vaccines for polio, hepatitis A, and hepatitis B. This issue looks into new technologies, particularly low-cost, high throughput sequencing of both genomic DNA and RNA that will provide vast amounts of new information on the genomes of many individual NHPs and gene expression patterns in multiple tissues from many animals. This information will provide new opportunities to make NHPs even more relevant to translational studies, but will also be a major challenge in terms of storage and interpretation. The field of NHP genetics and genomics is in a highly dynamic state, which is based on many past developments and the use of new high throughput technologies. In the next few years, the research community can expect further progress that should have a major impact on biomedical research.

 

Contents:

  • Progress in Genetics and Genomics of Nonhuman Primates
  • Great Ape Genomics
  • The Value of Extended Pedigrees for Next-Generation Analysis of Complex Disease in the Rhesus Macaque
  • Baboons as a Model to Study Genetics and Epigenetics of Human Disease
  • Systems Biology of the Vervet Monkey
  • Improving Genome Assemblies and Annotations for Nonhuman Primates
  • Nonhuman Primate Models in the Genomic Era: A Paradigm Shift
  • Old World Monkeys and New Age Science: The Evolution of Nonhuman Primate Systems Virology
  • The Essential Detail: The Genetics and Genomics of the Primate Immune Response
  • Haplessly Hoping: Macaque Major Histocompatibility Complex Made Easy
  • Progress and Prospects for Genetic Modification of Nonhuman Primate Models in Biomedical Research
  • In Transition: Primate Genomics at a time of Rapid Change
  • IACUC Review of Nonhuman Primate Research

Volume 54, Issue 1

Ethical and IACUC Considerations for Field Biology Studies

Scientific Editors: Mark Wallace and Howard Curzer

 

Ecological research often involves studies of wild animals in the field  to explore ecosystem function, autecology, or options for the management and long term survival of wildlife species or populations under growing human pressures. Although modeling approaches are sometimes helpful, field studies of animals are typically the only way to test hypotheses and develop realistic management strategies in disciplines such as ecology, wildlife management, and conservation biology. The Animal Welfare Act (AWA 1990), Public Health Service Policy on Humane Care and Use of Laboratory Animals (NIH 2002), and the Guide for the Care and Use of Laboratory Animals (NRC 2011) determine what practices are acceptable in laboratory animal research, but are almost completely silent about field research. Regulations developed for laboratory environments and domesticated taxa are increasingly extrapolated to the field, even though this extrapolation is typically inappropriate because of significant differences between laboratory research and field research on animals (Gannon et al. 2007).

 

This special issue includes papers by field biologists, veterinarians, social scientists, and philosophers who help explore the variety of ethical issues involved in ecological field research. It brings together diverse views about the ethical and welfare concerns involved in ecological field research and aims to expand investigators’, IACUCs’, and granting agencies’ understanding of the additional ethical considerations required when studying wild animals.

 

Contents:

  • Introduction: Moral Problems and Perspectives for Ecological Field Research
  • Fundamental Differences between Wildlife and Biomedical Research
  • Wildlife Researchers Running the Permit Maze
  • Ethical Issues in African Great Ape Field Studies
  • Falling through the Cracks: Shortcomings in the Collaboration between Biologists and Veterinarians and Their Consequences for Wildlife
  • Ecological Ethics in Captivity: Balancing Values and Responsibilities in Zoo and Aquarium Research under Rapid Global Change
  • The Ethics of Wildlife Research: A Nine R Theory
  • Setting Up an Ethics of Ecosystem Research Structure Based on the Precautionary Principle 

 

 

Future Issue Topics*

Vol 55(1): Naturally Occurring Diseases in Animals: Contributions to Translational Medicine

Vol 55(2): Behavioral Assessment in Animal Models: relevance for Human Psychopathology

Vol 55(3): Experimental design and statistics in laboratory animal research

Topics and titles are subject to change

 

Past Issue Topics

Vol 53(3-4): Epigenetics

Vol 53(2): Zebrafish Health and Husbandry

Vol 53(1): Neurobiology of Addiction-like Behaviors

Vol 52(3): Animal Models of Drug Addictions:  High Hopes for Therapeutic Treatments

Vol 52(2): Spineless Wonders: Welfare and Use of Invertebrates in the Laboratory and Classroom

Vol 52(1): Animal Models of Aging: Something Old, Something New

Supplement 1:  Proceedings of the Symposium on Animal Welfare and Scientific Research: 1985 - 2000

Vol 51(4): Birds as Animal Models in the Behavioral and Neural Sciences

Vol 51(3): One Health:  The Intersection of Humans, Animals, and the Environment

Vol 51(2): Disaster Planning and Management

Vol 51(1): Regenerative Medicine: From Mice to Men

 

For information on volumes of the ILAR Journal prior to 2010, please visit the Oxford Journals' archive site.