Current Issue

Volume 52, Issue 2
Spineless Wonders: Welfare and Use of Invertebrates in the Laboratory and Classroom
Scientific Editor: Stephen A. Smith

"All animals are equal, but some animals are more equal than others." - George Orwell, Animal Farm This much-needed issue of the ILAR Journal sheds light on the importance, versatility, and care and welfare requirements of invertebrates. The authors present both practical and philosophical matters in ways that will be broadly accessible and useful to those who interact with these underappreciated species. The articles cover four major aspects of invertebrate care and use in the laboratory, classroom, or elsewhere: 1. Use of invertebrates in biomedical and related research 2. The culture and maintenance of invertebrates 3. Evidence for pain and suffering and their alleviation 4. Attitudes and their influence on regulation and oversight This issue, which also includes an extensive compendium of invertebrate-related Web resources, is intended as a useful resource for a broad constituency of investigators, laboratory animal personnel, institutional officials for research, and members of animal care and use committees.

Contents:

• Introduction: Laboratory Invertebrates: Only Spineless, or Spineless and Painless?
• Invertebrate Models for Biomedical Research, Testing, and Education
• Culture and Maintenance of Selected Invertebrates in the Laboratory and Classroom
• Invertebrate Resources on the Internet
• Pain and Suffering in Invertebrates?
• Nociceptive Behavior and Physiology of Molluscs: Animal Welfare Implications
• Anesthesia, Analgesia, and Euthanasia of Invertebrates
• Philosophical Background of Attitudes toward and Treatment of Invertebrates
• IACUC Challenges in Invertebrate Research

Previous Issue*

Volume 52, Issue 1
 Animal Models of Aging: Something Old, Something New (February 2011)
Scientific Editor: Richard L. Sprott

• Introduction: Animal Models of Aging: Something Old, Something New
• Mice as a Mammalian Model for Research on the Genetics of Aging
• Heterogeneous Stocks and Selective Breeding in Aging Research
• The Collaborative Cross: A Recombinant Inbred Mouse Population for the Systems Genetic Era
• Mindspan: Lessons from Rat Models of Neurocognitive Aging
• Successful Aging and Sustained Good Health in the Naked Mole Rat: A Long-Lived Mammalian
• Model for Biogerontology and Biomedical Research
• The Marmoset as a Model of Aging and Age-Related Diseases
• Calorie Restriction and Aging in Nonhuman Primates
• The Development of Small Primate Models for Aging Research
• An IACUC Perspective on Songbirds and Their Use in Neurobiological Research

Next Issue*

Volume 52, Issue 3
Animal Models of Addictions to Drugs and Other Controlled Substances  (Summer 2011)
Scientific Editors: Kimberlei A. Richardson and Gabrielle L. McLemore

• Alcohol Addiction: Strengths and Limitations of Translational Models for Interactions of Stress and Alcohol Drinking
• Nicotine Addiction: Behavioral Abnormalities following Prenatal/Neonatal Nicotine Exposure in Rodents
• Marijuana Addiction: Marijuana Dependence: Not Just Smoke and Mirrors
• Opiate Addiction: The Role of Narp in Limbic System Plasticity: Relevance to Drug Abuse
• Ketamine Addiction: The Behavioral Pharmacology of Ketamine: Implications for Drug Abuse, Addiction, and Psychiatric Disorders
• Cocaine Addiction: Cracking the Molecular Code of Cocaine Addiction
• Methamphetamine Addiction: Nucleus Accumbens Invulnerability to Methamphetamine Neurotoxicity
• IACUC Considerations

Future Issue Topics*

• 52(4): Neurobiology of Addictive Behaviors (fall 2011)
• 53(1): Zebrafish Health and Husbandry (winter 2011-2012)
• 53(2): Epigenetics (spring 2012)
• 53(3): Prosthetics (summer 2012)
• 53(4): Zebrafish Models (fall 2012)

* Topics and titles are subject to change

Also forthcoming: A special supplemental issue of the ILAR Journal devoted to the proceedings of the October 2010 NIH/OLAW Symposium on Animal Welfare and Scientific Research: 1985-2010.

We welcome submission to the ILAR e-Journal of articles to complement future issue topics. Contact Managing Editor Cameron Fletcher for more information.

Recent ILAR Journal Issues

Vol 52(1): Animal Models of Aging: Something Old, Something New
Vol 51(4): Birds as Animal Models in the Behavioral and Neural Sciences
Vol 51(3): One Health: The Intersection of Humans, Animals, and the Environment
Vol 51(2): Disaster Planning and Management
Vol 51(1): Regenerative Medicine: From Mice to Men
Vol 50(4): Pain and Distress in Fish
Vol 50(3): Sleep-Disordered Breathing: Exploring a Human Disorder Using Animal Models
Vol 50(2): Gene Therapy in Large Animal Models of Human Genetic Disease
Vol 50(1): The Neurobiology of Social Behavior
Vol 49(4): Postapproval Monitoring...Balancing Risk Management with Burden
Vol 49(3): Detection and Management of Microbial Contamination

Subscription and Ordering Information

Please note that as of January 1, 2010, lost or missing issues will be replaced at the rate of $15 per copy, subject to a $5 shipping and handling fee.

Place your order online and get discounted pricing
Place your order at www.ilarjournal.com and get $5 off the cover price of individual issues. (Orders placed by telephone or fax are billed at $40 per issue.)

Articles and issues of the ILAR Journal can be ordered and downloaded online at www.ilarjournal.com (overnight delivery for print copies available within the US only). For more information visit www.ilarjournal.com/info.html, call 202-334-2590 or email ilarj@nas.edu.

Get up to 47% off the cover price
Annual individual subscriptions are $75 for US residents and $90 for international subscribers. Each subscription includes four issues of the ILAR Journal (published quarterly), a discount on National Academies Press publications, and a copy of the Guide for the Care and Use of Laboratory Animals upon request. Also, check out ILAR's institutional subscriptions (see below).

Institutional subscribers get immediate online access
Ask your institution to join ILAR's Associate Program to get immediate online access to the most recent full-text articles as well as multiple print copies of the ILAR Journal, and more. For more information, contact Jason Worthy at jworthy@nas.edu.

Recently Published

	Recognition and Alleviation of Pain in Laboratory Animals This book aims to educate laboratory animal veterinarians; students, researchers and investigators; institutional animal care and use committee (IACUC) members; animal care staff; and animal welfare officers on the current scientific and ethical issues associated with pain in laboratory animals. Report Website | Report Brief | Full Report
	Scientific and Humane Issues in the Use of Random Source Dogs and Cats in Research Animal welfare advocates, policymakers, and concerned pet owners will find this a vital and informative work for reconciling the needs of research with the welfare of animals. News Release | Report Brief | Full Report
	Pet Owner Fact Sheets Distilling information from the new Pain report, ILAR has produced fact sheets to help pet owners recognize symptoms of pain in dogs, cats, and other companion animals.

Selected References

• Guide for the Care and Use of Laboratory Animals
• Recognition and Alleviation of Distress in Laboratory Animals
• Science, Medicine, and Animals
• Principles for the Care and Use of Animals in Precollege Education 

 Did you know that ILAR project information is available online?

The National Academies announces meetings that are open to the public via the Current Projects System (CPS) at least 10 days before the event.

To learn more, visit the Current Projects System FAQ.

CALENDARS, MEETINGS, AND WORKSHOPS

AAALAC Conference Calendar
www.aaalac.org/news/calendar.cfm

AALAS Meetings and Events Calendar
www.aalas.org/calendar/index.asp

AVMA Calendar
http://www.avma.org/meetings/calendar/default.asp

Charles River Courses and Seminars (U.S.)
www.criver.com/en-US/NewsEvents/CourseSeminar/Pages/home.aspx

IAT/LASAT Calendar
www.lasat.org.uk

Jackson Laboratory Courses, Meetings, and Workshops Calendar
www.jax.org/courses/current.html

OLAW IACUC Staff Outreach Seminar Schedule
grants.nih.gov/grants/olaw/e-seminars.htm

University of Utrecht Course Calendar
http://www.lasat.org.uk/

25th annual Charles River Short Course
June 20-23, 2011
Newton, Massachusetts (Marriott Hotel)
Online Registration at www.criver.com/shortcourse20

Massachusetts General Hospital / Harvard Medical School:

• The Virtual Vivarium, a website created by Massachusetts General Hospital / Harvard Medical School Center for Comparative Medicine, is dedicated to management innovations in laboratory animal care. This resource provides white papers, presentations, management tools, case studies, and recommended reading for managers of large and diversified lab animal care programs. To learn more, visit Virtual Vivarium or email mghccm@partners.org.

• The FAQ on laparoscopic procedures has been updated. This guidance can be found in the Animal Use and Management section under FAQ F13. For questions, suggestions or comments, email olaw@od.nih.gov.


• What Investigators Need to Know About the Use of Animals provides a succinct resource for investigators to quickly grasp expectations and requirements when using animals in research supported by the PHS. Contact OLAW at olaw@od.nih.gov for hard copies, include number of copies needed and a complete mailing address.


• OLAW offers booklets on enrichment for nonhuman primates commonly used in education, research, and entertainment. The six booklets were codeveloped with the Association of Primate Veterinarians, American Society of Primatologists, and USDA Animal Care. Download booklets or request hard copies here

• Copies of the 2007 revision of Research Animal Anesthesia, Analgesia, and Surgery are available. To order, visit SCAW.

The Guide for the Care and Use of Laboratory Animals (8th edition)

• The Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts to incorporate new scientific information on commonly used laboratory animals, including aquatic species, and provides extensive references. The Guide makes recommendations for humane animal care and use based on published data, scientific principles, expert opinion, and experience with methods and practices proven consistent with high-quality research and humane animal care and use.

Animal Research in a Global Environment: Meeting the Challenges
Proceedings of an ILAR International Workshop

• As global demands for health care increase, animal research will continue to play a vital role. The trend toward globalization in health research is driving a need for international harmonization of principles and standards of animal care. The Institute for Laboratory Animal Research (ILAR) supports such harmonization by organizing workshops to promote dialogue on international issues in animal research. In 2008, ILAR convened a workshop on Animal Research in a Global Environment: Meeting the Challenges, bringing together 200 participants from 17 countries with a diversity of perspectives to consider topics such as veterinary training, animal transport, outsourcing, standards of animal care and welfare, and databases and repositories. The workshop has had an enduring impact for colleagues and organizations around the world in efforts to advance initiatives that will address gaps in standards, professional qualifications, and coordination of animal use.