What's New @ ILAR e-Newsletter -- Summer 2015

ILAR Roundtable on Science and Welfare in Laboratory Animal Use

The ILAR Roundtable held our first workshop, Reproducibility Issues in Research with Animals and Animal Models in Washington, DC on June 4-5. The inaugural workshop was well attended by leaders in academia, industry, and the non-profit arena who are concerned with the welfare and use of laboratory animals in scientific research. The presentations of all speakers, as well as a video and audio recording of the event, are located here:  http://nas-sites.org/ilar-roundtable/roundtable-activities/reproducibility/webcast/


Our second workshop, on Transportation of Laboratory Animals, was also well-attended and provided an engaging, insightful discussion on the issues surrounding the national and international transportation of laboratory animals. The presentations of all speakers, as well as a video and audio recording of the event, are located here:  http://nas-sites.org/ilar-roundtable/webcast-video-archive-transportation-2/


Our third workshop on Design, Implementation, Monitoring and Sharing of Performance Standards, took place on April 20-21, 2015 in Washington DC and was a two-day workshop including multiple national and international speakers from industry and academia. The Workshop also included an interactive session where attendees created their own performance standard and regulations, providing an in-depth look at the complexities of developing such a standard. Presentations of all speakers, as well as a video and audio recording of the event, are located here:  http://nas-sites.org/ilar-roundtable/roundtable-activities/performance-standards/


Please Save the Date for our next workshop, which will be held on December 7-8, 2015. The topic will be announced in the coming months - stay tuned!


Recent Issues of the ILAR Journal

Volume 56, Issue 1:  Livestock Models in Translational Science

Scientific Editors:  James A. Roth and Christopher K. Tuggle

This issue of the ILAR Journal focuses on livestock models in translational medicine. Livestock models of selected human diseases present important advantages as compared with rodent models for translating fundamental breakthroughs in biology to useful preventatives and therapeutics for humans. Livestock reflect the complexity of applying medical advances in an outbred species. In many cases, the pathogenesis of infectious, metabolic, genetic and neoplastic diseases in livestock species more closely ressembles that in humans than does the pathogensis of rodent models. Livestock models also provide the advantage of similar organ size and function and the ability to serially sample an animal throughout the study period. 

Articles include:

  • The Transmissible Spongiform Encephalopathies of Livestock
  • Mycobacterium bovis Infection of Cattle and White-Tailed Deer:  Translational Research of Relevance to Human Tuberculosis
  • Swine as a Model for Influenza A Virus Infection and Immunity
  • Large Animal Models for Vaccine Development and Testing
  • Human Microbiota-Associated Swine: Current Progress and Future Opportunities
  • Livestock Models for Exploiting the Promise of Pluripotent Stem Cells
  • Beyond the Mouse Monopoly:  Studying the Male Germ Line in Domestic Animal Models
  • Ovine Pulmonary Adenocarcinoma:  A Large Animal Model for Human Lung Cancer
  • Porcine Models of Muscular Dystrophy
  • Porcine Models of Cutaneous Wound Healing
  • IACUC Considerations for the Use of Livestock in Translational Research


Past Issues

Vol 55(3):  Experimental Design and Statistics

Scientific Editors: Michael Festing and Timo Nevalainen

Vol 55(2):  Behavioral Assessment in Animal Models:  Relevance for Human Psychopathology

Scientific Editors: Melinda A. Novak and Jerrold S. Meyer

Vol 55(1):  Naturally Occurring Diseases in Animals:  Contributions to Translational Medicine

Scientific Editor: Michael D. Lairmore and Chand Khanna

Future Issue Topics*

Vol 56(2): One Health: Livestock Models in Translational Science

Vol 56(3): Wildlife Diseases as Models for Research

Vol 57(1): Models of Viral-Induced Carcinogensis and Oncolytic Viruses

* Topics and titles are subject to change



Subscription and Ordering Information


The ILAR Journal is now being published by the Oxford University Press. New subscriptions, renewals, and single issues and articles from past issues are all available at the Oxford University Press website.



Recently Published

Guide for the Care and Use of Laboratory Animals: Eighth Edition (2011)

This seventh update to the Guide for the Care and Use of Laboratory Animals integrates recently published data, scientific principles, and expert opinion to recommend practices for the humane care and use of animals in research, testing, and teaching. The Guide is an internationally accepted primary reference on animal care for the scientific community. Previous editions have served as the basis for accreditation of institutions worldwide by the Association for Assessment and Accreditation of Laboratory Animal Care International. Also, use of previous editions has been required for researchers supported by the National Institutes of Health who adhere to the Public Health Service policy. Additions to this eighth edition of the Guide include expanded coverage of the ethics of laboratory animal use; components of effective Animal Care and Use Programs; new guidelines for the housing, environment, and enrichment of terrestrial and aquatic animals; updated information on veterinary and clinical care, and discussion of animal biosecurity.


Animal Research in a Global Environment (2011)

To identify and promote better understanding of the challenges of conducting animal research across country boundaries, the Institute for Laboratory Animal Research (ILAR) convened a workshop on Animal Research in a Global Environment: Meeting the Challenges, drawing on the expertise and perspectives of 200 participants from 17 countries. The public workshop featured invited presentations and discussions that focused on new information published since the last workshop in 2003, in part to inform the continuing development of guidelines (including an update of the 1996 Guide for the Care and Use of Laboratory Animals).



Animal Models for Assessing Countermeasures to Bioterrorism Agents (2011)

In response to a request by the Department of Defense, this report addresses the challenges stemming from developing and testing medical countermeasures in animal models. The report makes the principal point that a comprehensive strategy to improve data gathering and data sharing from animal models (or their alternatives) would significantly increase the efficiency and productivity of research into countermeasures while improving the humane use of laboratory animals in accordance with the principles of the Three Rs.


Guidance for the Description of Animal Research in Scientific Publications (2011)

This a short report aimed at editors of Journals that publish animal studies. The report outlines the information that should be included in scientific papers regarding such studies to ensure that the studies can be replicated. Necessary information includes conditions of housing and husbandry, genetic nomenclature, microbial status, detailed experimental manipulations, and handling and use of pharmaceuticals.


International Animal Research Regulations: Impact on Neuroscience Research (2012)

Animals are widely use in neuroscience research to explore biological mechanisms of nervous system function, to identify the genetic basis of disease states, and to provide models of human disorders and diseases for the development of new treatments. To ensure the humane care and use of animals, numerous laws, policies, and regulations are in place governing the use of animals in research, and certain animal regulations have implications specific to neuroscience research. This report summarizes the workshop “U.S. and European Animal Research Regulations” convened by the Institute of Medicine Forum on Neuroscience and Nervous System Disorders, in collaboration with the National Research Council Committee on Science, Technology, and Law, and the Institute for Laboratory Animal Research, held in the UK on July 26-27, 2011.


Did you know that ILAR project information is available online?

The National Academies announces meetings that are open to the public via the Current Projects System (CPS) at least 10 days before the event.

To learn more, visit the Current Projects System FAQ.



The International Council for Laboratory Animal Science (ICLAS) recently released guidelines for researchers, as well as editors and reviewers of scientific journals, regarding the ethics of using animal models in research. 


You can access both sets of guidelines at the ICLAS website.




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