ILAR Journal

Recent Issues of the ILAR Journal

Volume 57, Issue 1

Models of Viral-Induced Carcinogenesis and Oncolytic Viruses

Scientific Editors: Michael D. Lairmore and Stefan Niewiesk


This issue of the ILAR Journal explores research on models of viral-induced carcinogenesis and oncolytic viruses. The articles explore how viruses, bacteria and parasites have been linked to tumors in animals and humans; how viruses cause alteration of physiologic control of cell growth and proliferation and increase the susceptibility of the host to other cancer risk factors; and how some viruses may be used as agents against cancer.



  • Animal Models of Human T Cell Leukemia Virus Type I Leukemogenesis
  • Lessons Learned from Mouse Mammary Tumor Virus in Animal Models
  • Role of Feline Immunodeficiency Virus in Lymphomagenessis - Going Alone or Colluding?
  • Characterization of New Zealand White Rabbit Gut-Associated Lymphoid Tissues and Use as Viral Oncology Animal Model
  • Transgenic Mouse Models of SV40-Induced Cancer
  • Murine Models of Epstein-Barr Virus-Associated Lymphomagenesis
  • Preclinical Mouse Models for Analysis of the Therapeutic Potential of Engineered Oncolytic Herpes Viruses
  • Murine Tumor Models for Oncolytic Rhabdo-Virotherapy
  • Institutional Animal Care and Use Committee Considerations Regarding the Use of Virus-Induced Carcinogenesis and Oncolytic Viral Models

Volume 56, Issue 3

Insight Gained from Wildlife Research in the Context of Global Anthropogenic Change

Scientific Editors: Robert S. Sikes and John A. Bryan, II


The papers in this issue of the ILAR Journal examine the fundamental differences that exist between wildlife research objectives and those central to laboratory-based research using traditional laboratory animals. In traditional laboratory animal research, the purpose often involves obtaining greater clarity of some aspect of human health through the manipulation of non-human animal models. Such is rarely the case with wildlife research because the beneficiaries of these activities are almost invariably the very species under study. The results of wildlife research may also serve the broader ecosystem in which the study animals reside. This issue of the Journal explores all of the issues associated with studying wildlife rather than more traditional laboratory animals.



  • Commentary: Guidance for Field Biology and Other Studies on Wildlife Species
  • Balancing the costs of Wildlife Research with the Benefits of Understanding a Panzootic Disease, White-Nose Syndrome
  • Review of Elephant Endotheliotropic Herpesviruses and Acute Hemorrhagic Disease
  • Polyomavirus and Naturally Occuring Neuroglial Tumors in Raccoons (Procyon Lotor)
  • Wildlife Pathology Studies and How They Can Inform Public Health
  • Animal Welfare Policy: Implementation in the Context of Wildlife Research - Policy Review and Discussion of Fundamental Issues
  • Institutional Animal Care and Use Committee Considerations for the Use of Wildlife in Research and Education

Volume 56, Issue 2

The Microbiome: Modeling for Health and Disease

Scientific Editors: James G. Fox and Andre Bleich


In this issue are assembled papers that describe the emerging field centered on the microbiome of vertebrate animals and how these complex microbial populations play a fundamental role in shaping homeostasis of the host. The content of the papers will deal with bacteria and, because of relative paucity of information on these organisms, will not include discusions on viruses, fungus, porotzoa, and parasites that colonize various animals. Dissecting the number and interactions of the 500-1000 bacterial species that can inhabit the intestines of animals if made possible by advanced DNA sequencing methods, which do not depend on whether the organism can be cultured or not. Laboratory animals, particularly rodents, have proven to be an indispensable component in not only understanding the relationship of various species of bacteria to development of the immune system.



  • The Mammalian Microbiome and Its Importance in Laboratory Animal Research
  • Pathogens, Commensal Symbionts, and Pathobionts: Discovery and Funcational Effects on the Host
  • An Update on the Status of Current Research on the Mammalian Microbiome
  • The Altered Schaedler Flora: Continued Applications of a Defined Murine Microbial Community
  • Intestinal Microbiota in Animal Models of Inflammatory Diseases
  • The Intestinal Microbiota in Inflammatory Bowel Disease
  • Manipulating the Gut Microbiota: Methods and Challenges
  • Xenobiotics: Interaction with the Intestinal Microflora
  • Analyses of Intestinal Microbiota: Culture versus Sequencing
  • Maintaining and Monitoring the Defined Microbiota Status of Gnotobiotic Rodents
  • A Rewview of Applied Aspects of Dealing with Gut Microbiota Impact on Rodent Models



Future Issue Topics*

Vol 57(2): International Laws, Regulations, and Guidelines for Animal Research

Vol 57(3): Technology and Refinement in Animal Research

Vol 58(1): Genomics and Informatics for Translational Animal Models

Topics and titles are subject to change


Past Issue Topics

Vol 56(1): Livestock Models in Translational Science

Vol 55(3): Experimental Design and Statistics

Vol 55(2): Behavioral Assessment in Animal Models: Relevance for Human Psychopathology

Vol 55(1): Naturally Occurring Diseases in Animals: Contributions to Translational Medicine

Vol 54(3): Animal Models of Peripheral Neuropathy

Vol 54(2): Progress in Genetics and Genomics if Nonhuman Primates

Vol 54(1): Ethical and IACUC Considerations for Field Biology Studies

Vol 53(3-4): Epigenetics

Vol 53(2): Zebrafish Health and Husbandry

Vol 53(1): Neurobiology of Addiction-like Behaviors

Vol 52(3): Animal Models of Drug Addictions:  High Hopes for Therapeutic Treatments

Vol 52(2): Spineless Wonders: Welfare and Use of Invertebrates in the Laboratory and Classroom

Vol 52(1): Animal Models of Aging: Something Old, Something New

Supplement 1:  Proceedings of the Symposium on Animal Welfare and Scientific Research: 1985 - 2000

Vol 51(4): Birds as Animal Models in the Behavioral and Neural Sciences

Vol 51(3): One Health:  The Intersection of Humans, Animals, and the Environment

Vol 51(2): Disaster Planning and Management

Vol 51(1): Regenerative Medicine: From Mice to Men


For information on volumes of the ILAR Journal prior to 2010, please visit the Oxford Journals' archive site.