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Journal Vol 48(3)

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IACUC Issues Associated with Amphibian Research

Leanne C. Alworth and Stephen B. Harvey

Leanne C. Alworth, D.V.M., M.S., DACLAM, and Stephen B. Harvey, D.V.M., M.S., DACLAM, are Assistant Professors in the Department of Population Health, College of Veterinary Medicine, and Assistant Directors of University Research Animal Resources, University of Georgia, Athens, GA.

Address correspondence and reprint requests to Dr. Stephen B. Harvey, 206 Animal Resources, College of Veterinary Medicine, University of Georgia, 501 D.W. Brooks Drive, Athens, GA 30602, or email sbharvey@uga.edu.

Abstract

Numerous species of amphibians are frequently utilized as animal models in biomedical research. Despite their relatively common occurrence as laboratory animals, the regulatory guidelines that institutional animal care and use committees (IACUCs) must employ provide little in the way of written standards for ectothermic animals. Yet, as vertebrates, laboratory amphibians are covered by the National Research Council Guide for the Care and Use of Laboratory Animals and the Public Health Service (PHS) Policy for federally funded research. This article focuses on three issues that are relevant to IACUC oversight of the use of amphibians in research: (1) recommended educational requirements of investigators and animal care staff engaged in research with amphibians, (2) zoonoses and other issues of occupational health importance, and (3) indicators of stress and disease. Addressing these issues should enable investigators, IACUCs, and animal care staff to meet the regulatory expectations of the PHS and accrediting bodies such as the Association for Assessment and Accreditation of Laboratory Animal Care International.

Key Words: amphibian; education; IACUC; occupational; research; stress; zoonosis